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    Latest Osteoporosis News - October 27th 2009

    General Osteoporosis and Lifestyle News

    The Wall Street Journal (Subscription only), reports that the FDA has delayed it's decision on whether to approve Amgen's new osteoporosis drug Denosumab (to be produced under the name Prolia). The FDA is awaiting more information from the company on their risk management strategy for older women. Due to the nature of the FDA's request it is expected that Amgen will be able to respond to the demands fairly quickly, nonetheless the share prices of Amgen dropped over 1%, and according to Bloomberg if Amgen is eventually successful in its two applications to the FDA (one related to post menopausal osteoporosis and the other to oncology) are approved then it is forecast that Prolia may have sales of $3billion per annum.

    What is Denosumab? Denosumab is a RANK ligand blocking antibody; It therefore works by blocking the action of RANK ligands in the breakdown of bones during the bone remodelling cycle.

    Vitamin D plays a very important role in bone health and deficiencies in this vitamin are known to be one of the major osteoporosis risk factors. A report on the PrivateMDLabs website states that over six million children in the USA do not get enough of the vitamin; as well as its role in osteoporosis vitamin D is known to enhance ones immunity system.

    WebMD reports that research into the vegetable lamb plant (Cibotium barometz) may one day lead to the development of osteoporosis treatments as a compound(s) found in the vegetable lamb plant was able to block the action of osteoclasts (which are involved in the bone remodelling cycle.

    Latest Osteoporosis Research

    McNicholl and Heaney from the Queen's University of Belfast report on the safety implications of bisphosphonates when used to treat pre-menopausal women who are taking corticosteroids. The article has been published online in advance of an April 2010 publication date in the current drug safety journal. They mention that one of the problems associated with glucocorticoid therapy, which is used to treat many chronic conditions, is that it has many side effects including that of osteoporosis. Therefore bisphosphonates are often used in conjunction with corticosteroids as a prevention measure. They go on to discuss animal study findings and discuss how these may relate to humans. They recommend that a study should be carried out on the implications of bisphosphonate use in pregnant women and in premenstrual women who are planning on starting a family.

    Mazière and colleagues from the INSERM ERI-12 in France report on their work with RANK ligands (the target of Amgen's Prolia drug mentioned above) in the Journal of cellular physiology. They look at the effect that copper oxidized LDL (OxLDL) has on RANK ligand signalling pathways and on osteoclast differentiation. They conclude that OxLDL is able to generate an intracellular oxidative stress, which in turn prevents osteoclast differentiation through the inhibition of RANK ligand signalling pathways; in turn this will have an impact on both vascular calcification and the development of osteoporosis.

    Featured Osteoporosis Site

    Just a short shout out to ExerciseIsMedicine, who have released a fact sheet on recommended exercise techniques for people suffering from 40 different conditions; one of which is osteoporosis. Although the available osteoporosis pdf's do not contain exercises per se, they do contain important information that may help to prevent injuries.

    Recommended Reading

    Today we recommend that you take a look at our pages on exercise and nutrition osteoporosis influences. The article discusses how balancing exercises can help to increase balance, therefore lowering the risk of falls and gaining a fracture. Also discussed are how nutritional intakes such as calcium and vitamin D act to maintain bone strength.

    More Osteoporosis News