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    Latest Osteoporosis News - September 7th 2009

    General Osteoporosis and Lifestyle News

    The wall street journal runs a report on the Merck Fosamax trial. In the trial 71 year old Shirley Boles claims that the reason she has developed osteonecrosis is due to her taking the osteoporosis drug Fosamax. The lawyers for Merck defend themselves by stating that Shirley Merck has a history of dental problems and stopped taking the drug three years before she developed jaw necrosis. The lawyer for Ms. Burke claims that Merck failed to notify the public about the potential side effects, such as osteonecrosis, of the fosamax drug. The case has currently gone to jury.

    The new york times reports that the drug denosumab, which is produced by Amgen has received a partial approval by the FDA. It has been approved for use to treat osteoporosis in postmenopausal women, but was not approved for those who have only low bone density loss. The FDA also did not approve Amgen's denosumab osteoporosis drug for patients suffering either breast or prostate cancer as it was found in trials that denosumab slightly increased infections and cancers. Denosumab is therefore seen as a drug to be used for a high risk subgroup of osteoporosis suffers, those particularly at risk of getting fractures.

    Although Eli Lilly osteoporosis drug arzoxifene (the potential replacement drug for Evista, whose patent expires in 2014) passed most of its main phase III trial tests the company has decided not to seek FDA approval for the drug as it failed to increase many secondary (and important issues) such as non-vertebral fractures and clinical vertebral fractures. The drug also led to an increase in hot flushes in users (full report in the WSJ).

    Latest Osteoporosis Research

    It is well known that androgens protect bone, however poor oral availability and side effects have meant that their use in the treatment of osteoporosis is very limited. In this research article Kearbey and colleagues report that a tissue-selective androgen receptor modulator known as S4 was able to partially or completely recover bone parameters to age-matched intact levels in rats. They suggest that S4's ability to promote anabolism of bone, increase the sleletal muscle mass and to prevent the resorption of bone may put S4 forward as a future treatment for osteoporosis.

    Shin and colleagues report in the osteoporosis intenational journal that Postmenopausal Korean women who took a high intake of protein and dairy products had a lower risk of developing osteoppenia.

    Featured Osteoporosis SiteThis weeks featured site is WebMD. WebMD is one of the most well known and respected medical sites on the internet. The section on osteoporosis carries a well written and researched guide on both the prevention and treatment of the osteoporosis condition. The site also caries rewrites of the latest osteoporosis news stories so that they are understandable to the general public and advice on calcium.

    Recommended Reading

    Although you can combat the onset of osteoporosis by health eating (including lots of calcium and vitamin d in the diet) and by carrying out weight bearing exercises, your genes also have a large part to play in the likelihood of you developing osteoporosis. This section of the site takes a look at the relationship between genetics and osteoporosis .

    More Osteoporosis News