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    When both estrogen and progestin are given to a patient for the treatment of osteoporosis the procedure is known as hormone replacement therapy. This has the advantage over estrogen replacement therapy (ERT) in that it helps to reduce the risks of endometrial cancer. Nowadays the use of bisphosphanates is normally prescribed for people suffering from osteoporosis alone. However under some circumstances the use of hormone replacement therapy to certain kinds of patients. The information below is gearded towards this group.

    It is usual that a woman will take an estrogen supplement everyday, and will take progestin for a 13 day period. This enables the user of the hormone replacement therapy to choose when her bleeding will occur. If the patient takes the progesterone from the first day of the month, then she will bleed in the middle of the month, whereas if she was to take the progestin later the month, then she will bleed at the end of the month.

    It used to be the case that women would take a break in their estrogen intake after the third week; this often resulted in the women getting symptoms that were related to the stoppage of the hormone; these included hot flushes, tiredness/insomnia and becoming irritable. As progestin will cut the risk of endometrial cancer regardless of whether estrogen treatment is stopped or not, it appears a little daft to stop the intake of the hormone.

    Continuous combined hormone replacement method

    Another way of taking hormone replacement therapy is known as the continuous combined method. In this method the user will take progestin everyday as part of her osteoporosis related hormone replacement therapy. Although the patient is likely to bleed at somewhat unpredictable times for a six month period when following the continuous combined method, there is a high chance that she will stop bleeding altogether after this period. This is because the endometrium no longer responds to the continuous supply of progestin. This reduces the likelihood of developing endometrial cancer dramatically.

    There are other methods of hormone replacement therapies involving estrogen and progestin, one of which is to take the progestin every three months, this is seen as a compromise between the intake of supplemental hormones and the risk of developing endometrial cancers as shedding of the endometrium will occur every three months. For women who have undergone a hysterectomy there is no need to take progestin as there is no risk of developing endometrial cancer.