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  • If you want to prevent or treat osteoporosis in as natural way as possible, you will be pleased to know that I now have an Android App available - OsteoTrack.

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    There is a known link between the hormone estrogen and breast cancer, it has long been known that women who start menstruation at an early age, and hence are subjected to a longer period of estrogen production have a higher risk of breast cancer. Conversely women who enter the menopause early, and whose production of estrogen stops have a lower risk of breast cancer. The link between ovarian function and breast cancer has been known since 1986 and in the UK alone thirteen thousand deaths occur per annum as a consequence of breast cancer (reference: Kandall et al, Journal of steroid biochemistry and molecular biology, 2006).

    Things that influence oestradiol circulation.

    There are many complex factors that affect the levels of circulating oestradiols in postmenopausal women, and these are ultimately controlled by enzymes that are involved is the metabolism of steroids. The production of estrogens is dependent upon the mass of tissue that is available for oestradiol production, and is therefore partially dependent on the body mass index of the women; therefore the exercise and diet of the individual plays a major role in the amount of circulating estrogen throughout a persons life, and must be taken into account when considering the risks of breast cancer when undergoing hormone replacement treatment.

    As mentioned previously there is much circumstantial evidence linking an increased risk of breast cancer and estrogen levels. Recently both epidemiological and clinical evidence has become available to support these claims and it has been found that 17-b-estradiol plays a role in the induction of neoplastic transformation in the epithelial cells of human breasts (Russo and Russo, Journal of steroid biochemistry and molecular biology, 2006).

    Blocking estrogen receptor modulators in the fight against breast cancer.

    The use of non-steroidal selective estrogen receptor modulators such as tamoxifen, has been used in the fight against breast cancer since the seventies; it is estimated that its use has saved over four hundred thousand lives (Baker, current opinion in investigational drugs, 2006). One side effect however is an increased risk of cardiovascular diseases. The use of new non-steroidal inhibitors such as anastozole and letrozole have helped to eliminate some of the risks associated with tamoxifen; though the long term effects of the blocking of estrogen.

    Seek medical advice when taking hormone treatments for osteoporosis.

    Although there is a strong correlation between estrogen treatment and breast cancer, many factors have to be taken into account when taking hormone replacement treatments in the fight against osteoporosis. These need to be discussed in full with your doctor; your family history and other factors such as racial background, exercise regimes and whether you smoke or not all have a large impact upon the risk of breast cancer regardless of estrogen replacement therapy or not. All these factors need to be analysed in depth by you and your doctor when you make the decision to take oestrogens.