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    The relationship between estrogens supplementation and endometrial cancer is a very important question that many people are rightfully concerned about. There is a strong link between replacement of estrogen in postmenopausal women and endometrial cancer.

    Medical research has correlated the increased levels of estrogen with the likelihood of cancer of the lining of the uterus. Interestingly there was no correlation between cancer and women who took multi-hormone, estrogen and progesterone treatments. When took alone, estrogen increases the risk of developing cancer dramatically, it is estimated that taking the hormone alone for a ten year period would increase the likelihood of cancer by eight times.

    The link between progesterone and cancer

    Research has demonstrated a link with endometrial cancer in premenstrual women who had abnormal menstruation patterns and did ovulate. If women do not ovulate an ovary is not produced and it can con develop into corpus luteum; this results in a loss of progesterone. Due to the links between estrogen, progesterone and endometrial cancer it was speculated that taking both hormones together would reduce the risks. It was found that women who took progesterone (in addition to estrogen) for a thirteen day period every month developed endometrial cancer at a rate only 15 percent of those who took estrogen alone.

    In fact the risk of endometrial cancer in women who take both estrogen and progesterone is actually ten percent lower than that seen in women who do not take hormone replacement treatments.

    How does progesterone help to prevent endometrial cancer?

    The addition of progesterone to a woman’s hormone replacement treatment results in a woman having a light period. What is actually happening is that once the progesterone is stopped being taken, the womb is signalled to shed the endometrium is shed; just like it is in a normal menstrual cycle.

    The risk and benefits of hormone replacement therapy

    Although the risk of endometrial cancer can be controlled by taking dual hormone treatments, and their use has also been shown to reduce the risks of colorectal cancers and bone fractures, there is a strong relationship between hormone supplements and other conditions such as breast cancer, strokes and coronary heart disease (Michelle Warren, American Journal of Obstetrics and Gynaecology, 2004). When making a decision on whether to take hormone replacement or other alternative osteoporosis treatments you should bear in mind that by endometrial cancer can be detected at an early stage by taking regular six month check ups with your doctor. The treatment of early stage endometrial cancer is relatively easy; it is one of the most successfully treated cancers.